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Clinical Review Report: Baricitinib (Olumiant): (Eli Lilly Canada Inc
among other effects
Formula: C59H89N19O13S
Yoav Elkis
InChiKey: ZSBXGIUJOOQZMP-JLNYLFASSA-N
ML216 Catalog No.:M8581-2 Clinical Review Report: Baricitinib (Olumiant):ML216, also known as CID 4985229, is a potent and selective inhibitor of Bloom (BLM) Helicase. ML216 displays low micromolar potency and selectivity over related helicases, such as RECQ1, RECQ5, and E. coli UvrD helicases. ML216 shows cell based activity and can induce sister chromatid exchanges, enhance the toxicity of aphidicolin, and exert antiproliferative activity in cells expressing BLM, but not those lacking BLM. ML216 shows strong selectivity