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CAS Number: 1239908-20-3
15)16)20-11-17-3-2-4-18-11/h2-4
This induces the unfolded protein response (UPR) and results in both the induction of tumor cell apoptosis and the inhibition of tumor cell growth
4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea
LDN-214117 exhibits a selective inhibition on BMP6 with IC50 of approximately 100 nM
CAL-130 Hydrochloride - CAS# 1431697-78-7 60153 CAS Number: 1239908-20-3CAL 130 is a potent and selective PI3K gamma and delta inhibitor with potential anticancer activity. Constitutive phosphoinositide 3 kinase (PI3K) Akt activation is common in T cell acute lymphoblastic leukemia (T ALL). Although four distinct class I PI3K isoforms (, , , ) could participate in T ALL pathogenesis, none has been implicated in this process. In the absence of PTEN phosphatase tumor suppressor function, PI3K or PI3K alone can support
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