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Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A
It has >10-fold selectivity PRMT5
InChi: InChI=1S/C16H17N5O2/c1-8-9(2)17-16(20-14(8)22)21-15-18-10(3)12-6-5-11(23-4)7-13(12)19-15/h5-7H
It inhibits PHD2 via binding to the 2OG binding site
AUY-922 shows great inhibition of pancreatic cancer cells with IC50 of at 10 nM
PROTAC CRABP-II Degrader-1 x (E1210) Inhibition of proliferation and survivalPROTAC CRABP II Degrader 1 is a potent cellular retinoic acid binding protein (CRABP II) degrader based on cIAp1. Product information CAS Number: 1225383 40 3 Molecular Weight: 764. 95 Formula: C42H60N4O9 Chemical Name: (2E, 4E, 6E) 9 [(3E) 3 [({[2 (2 {[(2S) 2 [(2S, 3R) 3 amino 2 hydroxy 4 phenylbutanamido] 4 methylpentanoyl]oxy}ethoxy)ethyl]carbamoyl}methoxy)imino] 2, 6, 6 trimethylcyclohex 1 en 1 yl] 3, 7 dimethylnona 2, 4, 6, 8 tetraenoic acid