HTH-01-015 - CAS# 1613724-42-7 Catalog No.:M6435-10 48(9):3344-53

48(9):3344-53

At 500 nM fMLP stimulation

Rapamycin is usually used at 1 µM final concentration in vitro and in cellular assays

Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives

Cyclopamine was administered at 50 mg/kg by subcutaneous injection once per day in tumor xenograft mouse model

HTH-01-015 - CAS# 1613724-42-7 Catalog No.:M6435-10 48(9):3344-53HTH 01 015, CAS No. 1613724 42 7, is a potent and selective inhibitor of NUAK1 (IC50 = 100 nM) and does not affect the activity of a panel of 139 other kinases, including additional AMPK family members. The administration of HTH 01 015 to MEFs (mouse embryonic fibroblasts) significantly inhibits migration in a wound healing assay to a similar extent as NUAK1 knockout. HTH 01 015 also inhibit proliferation of MEFs to the same extent as NUAK1 knockout