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CHIR99021 trihydrochloride - CAS# 1782235-14-6 Catalog No.:M6933-10 Inhibition of EP300 and DDR1

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Description

Inhibition of EP300 and DDR1 synergistically alleviates pulmonary fibrosis in vitro and in vivo

InChiKey: ADZBMFGQQWPHMJ-RHSMWYFYSA-N

12(1):163-7

Smiles: CC1=CC(NC2=CC(=CC=N2)NC(=O)C2C(Cl)=CC=CC=2Cl)=NC(N)=N1

24)25)12-27-21(30-20)28-15-7-8-17-14(9-15)10-19(32)29-17/h3-9

CHIR99021 trihydrochloride - CAS# 1782235-14-6 Catalog No.:M6933-10 Inhibition of EP300 and DDR1CHIR99021 trihydrochloride, CAS No. 1782235 14 6, also known as CT 99021, or CHIR 911, is an orally active and potent GSK3 inhibitor. CHIR 73911 exhibited GSK3 IC50 in the low nanomolar range and excellent selectivity. CHIR 73911 activates glycogen synthase in insulin receptorexpressing CHO IR cells and primary rat hepatocytes. Product information CAS Number: 1782235 14 6 Molecular Weight: 574. 72 Formula: C22H21Cl5N8 Related CAS Number: 252917 06 9

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