Delavirdine 805 dihydrochloride Taxol induces caspase-10-dependent apoptosis

Taxol induces caspase-10-dependent apoptosis

is a highly potent and selective inhibitor of DOT1L methyltransferase with Ki of 70 pM

It abrogated DNA damaged checkpoints induced by gemcitabine

Enzastaurin (LY317615) application results in a marked dose-dependent inhibition of growth in all MM cell lines investigated

InChi: InChI=1S/C24H29NO3

Delavirdine 805 dihydrochloride Taxol induces caspase-10-dependent apoptosisDelavirdine is a non nucleoside reverse transcriptase inhibitor (NNRTI). It is used as part of highly active antiretroviral therapy (HAART) for the treatment of human immunodeficiency virus (HIV) type 1. Although delavirdine was approved by the U. S. Food and Drug Administration in 1997, its efficacy is lower than other NNRTIs, especially efavirenz, and it also has an inconvenient schedule. These factors have led the U. S. DHHS not to recommend its