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A single treatment with GK921 almost completely reduced tumor growth by stabilizing p53 in the ACHN and CAKI-1 preclinical xenograft tumor models
CAS Number: 81686-22-8
consistent with an inhibition of both mTORC1 and mTORC2 complexes
Macdonald TL
35 μM for human PPARα
Strontium Ranelate Catalog No.:M9951-2 A single treatment with GK921Strontium Ranelate is a strontium(II) salt of ranelic acid, is a medication for osteoporosis. Studies indicate it can also slow the course of osteoarthritis of the knee. The drug is unusual in that it both increases deposition of new bone by osteoblasts and reduces the resorption of bone by osteoclasts. It is therefore promoted as a "dual action bone agent" (DABA). The use is now restricted to treatment of severe osteoporosis in postmenopausal women
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