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CAS Number: 4727-31-5
InChi: InChI=1S/C25H30N2O5/c1-15-21(24(29)32-18-7-5-4-6-8-18)22(16-9-11-17(12-10-16)27(30)31)23-19(26-15)13-25(2
(2015) PLoS One
p300 and CBP are transcriptional co-activators that modulate DNA replication
(2013) Nat Cell Biol
MHY1485 - mTOR Activator. CAS# 326914-06-1 Catalog No.:M60189-10S CAS Number: 4727-31-5MHY1485, CAS No. 326914 06 1, is a novel potent, selective and cell permeable mTOR activator. It suppressed the basal autophagic flux, and this inhibitory effect was clearly confirmed in cells under starvation, a strong physiological inducer of autophagy. It can increase cellular mTOR Ser2448 and downstream substrate 4E BP Thr37 46 phosphorylation level in rat liver Ac2F cells (1 to 2 M for 1 h). It affects culture viability only at much higher