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7a-tetrahydro-4H-furo[3
This suggests that GN44028 probably affected the transcriptional pathway induced by the HIF-1α/HIF-1β heterodimer
InChi: InChI=1S/C14H7ClFN3O5/c15-10-5-7(1-3-11(10)16)18-14(21)9(13(20)17-18)6-8-2-4-12(24-8)19(22)23/h1-6H
and triggers intrinsic SUMOylation of SERCA2a
24)25)10-13-2-1-12(9-16(13)22)19-27-11-33-28-19/h1-6
AAE-581 - CAS# 354813-19-7 60167 7a-tetrahydro-4H-furo[3Balicatib(AAE 581), CAS No. 354813 19 7, is a potent and selective inhibitor of cathepsin K; 10 100 fold more potent in cell based enzyme occupancy assays than against cathepsin B, L, and S. IC50 value: Target: cathepsin K The cathepsin K inhibitor AAE 581 (balicatib) as the most advanced of them passed Phase II clinical trials in 2005. Eighty adult female Macaca fascicularis underwent bilateral ovariectomies and were dosed twice daily by oral gavage
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