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Winzeler EA
InChi: InChI=1S/C23H35N5O2/c1-29-20-16-18-19(17-21(20)30-2)25-23(28-14-8-9-15-28)26-22(18)24-10-4-3-5-11-27-12-6-7-13-27/h16-17H
InChiKey: IJCMHHSFXFMZAI-UHFFFAOYSA-N
1247819-59-5
Twenty animals underwent sham-ovariectomies (group S)
AZD2014 - mTOR Inhibitor. CAS# 1009298-59-2 size:2 mg solid Winzeler EAAZD2014, CAS No. 1009298 59 2, is a highly potent, selective and ATP competitive mTOR inhibitor (IC50 = 2. 8 nM). It displays a high level of selectivity against other members of the PIKK family (IC50 against PI3K isoforms , , , = 3. 8 M, >30 M, >30 M and >29 M, respectively) and is inactive against a general panel of over 200 kinases when tested at 10 M. AZD2014 inhibits both mTORC1 and mTORC2 in vitro (pS6 (S235 236 ) IC50 = 0. 2 M, pAKT (S473) IC50
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