AMD-070 Hydrochloride - CAS# 880549-30-4 Catalog No.:M9954-10 2R-hydroxy-pentanedioic acid

2R-hydroxy-pentanedioic acid

even in the presence of BMSCs or exogenous IL-6

Its potency is around 70–90% that of prednisone

FH535 increases the radiosensitivity and reverses epithelial-to-mesenchymal transition of radioresistant esophageal cancer cell line KYSE-150R

5a-dihydroxy-4-(hydroxymethyl)-1

AMD-070 Hydrochloride - CAS# 880549-30-4 Catalog No.:M9954-10 2R-hydroxy-pentanedioic acidMavorixafor, also known as AMD11070, AMD070, X4P 001, is an orally bioavailable and potent CXCR4 inhibitor. AMD11070 is an antagonist of SDF 1 ligand binding (IC50 = 12. 5 1. 3 nM), inhibits SDF 1 mediated calcium flux (IC50 = 9. 0 2. 0 nM) and SDF 1 mediated activation of the CXCR4 receptor as measured by a Eu GTP binding assay (IC50 =39. 8 2. 5 nM) or a [(35)S] GTPS binding assay (IC50 =19. 0 4. 1 nM), and inhibits SDF 1 stimulated chemotaxis (IC50