CDK12-IN-E9 Size:Contact [email protected] for quotation Intraperitoneally injection of compound CA-074

Intraperitoneally injection of compound CA-074 into rats potently and selectively inhibits cathepsin B activity

Biotin alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs

NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |^1:0

Exposures (AUC) increases in a less than dose-proportional manner from 23 μM•h at 5 mg/kg to 362 μM•h at 500 mg/kg

InChiKey: HEGZERUHBVYZPH-UHFFFAOYSA-N

CDK12-IN-E9 Size:Contact [email protected] for quotation Intraperitoneally injection of compound CA-074CDK12 IN E9 is a potent and selective covalent CDK12 inhibitor and a non covalent CDK9 inhibitor, while avoiding ABC transporter mediated efflux. CDK12 IN E9 has weak binding ability to CDK7 CyclinH complex with an IC50> 1 M. Product information CAS Number: 2020052 55 3 Molecular Weight: 434. 53 Formula: C24H30N6O2 Chemical Name: N [3 ({3 ethyl 5 [(2S) 2 (2 hydroxyethyl)piperidin 1 yl]pyrazolo[1,5 a]pyrimidin 7 yl}amino)phenyl]prop 2 enamide Smiles: