Luotonin A NB 142-70 Chemical Name: N-(9-{[4-(dimethylamino)phenyl]amino}-6-[3-(pyrrolidin-1-yl)propanamido]acridin-3-yl)-3-(pyrrolidin-1-yl)propanamide trihydrochloride

Chemical Name: N-(9-{[4-(dimethylamino)phenyl]amino}-6-[3-(pyrrolidin-1-yl)propanamido]acridin-3-yl)-3-(pyrrolidin-1-yl)propanamide trihydrochloride

CN1CCN(CCCN2C3=CC=CC=C3SC3=CC=C(C=C23)C(F)(F)F)CC1

even in dormant or nonreplicating mycobacteria

which produced only extremely small amounts of Aβ42

NS(=O)(=O)OC[C@@H]1C[C@H](C[C@@H]1O)N1C=CC2C1=NC=NC=2N[C@H]1CCC2=CC=CC=C21

Luotonin A NB 142-70 Chemical Name: N-(9-{[4-(dimethylamino)phenyl]amino}-6-[3-(pyrrolidin-1-yl)propanamido]acridin-3-yl)-3-(pyrrolidin-1-yl)propanamide trihydrochlorideIC50: 1. 8 g mL for P 388 cell line Luotonin A binds to and stabilizes the topoisomerase I DNA binary complex. Topoisomerase DNA complexes have been reported as the primary target of several important antitumor agents. These agents have been shown to be able to increase the number of topoisomerase associated DNA strand breaks in cells, by stabilizing the covalent enzyme DNA complex and therefore diminishing the resealing of the DNA phosphodiester