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Tubastatin A Hydrochloride - CAS# 1310693-92-5 riquidar (methanesulfonate hydrate) LPS-induced TNF-alpha production in mice

SKU: 93051522525

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Description

LPS-induced TNF-alpha production in mice

When PERK inhibitors turn out to be new potent RIPK1 inhibitors: critical issues on the specificity and use of GSK2606414 and GSK2656157

Rolipram-treated A-172 cells undergo differentiation

is a p38 MAPK inhibitor with IC50 of 20 nM

InChi: InChI=1S/C13H17ClN2O2/c14-12-3-1-11(2-4-12)13(17)15-5-6-16-7-9-18-10-8-16/h1-4H

Tubastatin A Hydrochloride - CAS# 1310693-92-5 riquidar (methanesulfonate hydrate) LPS-induced TNF-alpha production in miceTubastatin A is a potent and selective HDAC6 inhibitor. Tubastatin A demonstrates 1093 fold selectivity over HDAC1 (IC50 values of 15 nM for HDAC6 vs 16. 4 M for HDAC1). Tubastatin A was substantially more selective than the known HDAC6 inhibitor Tubacin at all isozymes except HDAC8. Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM. Comparatively, it demonstrates over 1,000 fold selectivity against all other HDAC isoforms (IC50 >16

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