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is a potent and selective antagonist of the G protein-coupled receptor identified as EBI2 (GPR183) (IC50 values are 11 and 15 nM for human and mouse EBI2 receptors
P110δ-IN-1
Chemical Name: (Z)-3-(acetoxyimino)-5-chloro-1-(2
Solubility: DMSO: 71 mg/mL(198
Development and biological evaluation of potent and specific inhibitors of mitotic Kinesin Eg5
Roscovitine (Seliciclib) D318088 is a potent and selectiveSeliciclib, also known as roscovitine and CYC202, is a n orally bioavailable, small molecule cyclin dependent kinase (CDK) inhibitor with potential proapoptotic and antineoplastic activities. Seliciclib primarily inhibits CDK2 E, CDK2 A, CDK7 and CDK9 by competing for their ATP binding sites, leading to a disruption of cell cycle progression. In addition, this agent appears to interfere with CDK mediated phosphorylation of the carboxy terminal domain