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Acadesine induces apoptosis of B-CLL cells in a dose-dependent manner with EC50 of 380 μM
and biotinylated PFI-2 interacts with SETD7 in pull-down studies
AZ3451 is a potent antagonist of protease-activated receptor 2 (PAR2) that binds to a remote allosteric site outside the helical bundle with IC50 of 23 nM
demonstrating a concentration dependence of AAI101 on restoration of the antibacterial activity of the cephalosporin
KU-0063794 exhibits more significant potency to induce the complete dephosphorylation of 4E-BP1 at Thr37
Efinaconazole - CAS# 164650-44-6 eprazole Acadesine induces apoptosis of B-CLLEfinaconazole is a triazole antifungal. It is approved for use in Canada and the USA as a 10% topical solution for the treatment of onychomycosis (fungal infection of the nail). Efinaconazole acts as a 14 demethylase inhibitor. Efinaconazole inhibits fungal lanosterol 14 demethylase involved in the biosynthesis of ergosterol, a constituent of fungal cell membranes. Efinaconazole has been shown to be active against isolates of the following