TL 13-22 prasidone D8 59)60)10-9-21-5-6-22(23-7-8-26(40)30-32(23)57(17-37(43

59)60)10-9-21-5-6-22(23-7-8-26(40)30-32(23)57(17-37(43

Celastrol strongly inhibits LPS and IFN-y-induced NO production with IC50 of 200 nM in macrophage lineage cells

which may result in the inhibition of tumor angiogenesis and tumor cell proliferation

selective inhibitor of VEGFR-2 tyrosine kinase (IC50 = 0

Smiles: COC1C(=CC(=CC=1OC)C1=CC(=CN=C1N)C1=CC(O)=CC=C1)OC

TL 13-22 prasidone D8 59)60)10-9-21-5-6-22(23-7-8-26(40)30-32(23)57(17-37(43TL13 22 is a negative control for TL13 12 (HY 122582) and a potent ALK inhibitor with an IC50 of 0. 54 nM. TL13 22 does not degrade ALK in cells. Product information CAS Number: 2229036 65 9 Molecular Weight: 947. 50 Formula: C45H55ClN10O9S Chemical Name: N (2 {2 [2 (4 {4 [(5 chloro 4 {[2 (propane 2 sulfonyl)phenyl]amino}pyrimidin 2 yl)amino] 3 methoxyphenyl}piperazin 1 yl)ethoxy]ethoxy}ethyl) 2 {[1, 3 dioxo 2 (2 oxopiperidin 3 yl) 2, 3 dihydro 1H