GABAB receptor antagonist 1 13412 Afatinib impurity 11 is an

Afatinib impurity 11 is an impurity of Afatinib

inhibition at 24 hours (51%-78%) is almost comparable with that seen at 4 hours

Frustaci AM

InChiKey: UXHLCYMTNMEXKZ-PGMHMLKASA-N

InChi: InChI=1S/C29H36N4O3/c1-4-17-35-25-9-5-23(6-10-25)7-12-28-30-26-20-24(29-21(2)31-36-22(29)3)8-11-27(26)33(28)14-13-32-15-18-34-19-16-32/h5-6

GABAB receptor antagonist 1 13412 Afatinib impurity 11 is anGABAB receptor antagonist 1 (compound 14) is a selective and negative allosteric modulator of GABAB ( Aminobutyric acid) receptors. (E) GABAB receptor antagonist 1 decreases GABA induced IP3 (inositol trisphosphate) production with IC50 of 37. 9 M. Product information CAS Number: 797 17 1 Molecular Weight: 304. 38 Formula: C18H24O4 Chemical Name: (3E) 4 (3,5 di tert butyl 4 hydroxyphenyl) 2 oxobut 3 enoic acid Smiles: