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PubMed Central PMCID: PMC4471626
Chemical Name: 4-[(4R)-4-(hydroxymethyl)-3-methyl-2
HTH-01-015 will serve as useful chemical probes to delineate the biological roles of the NUAK kinases
caspase-3 and caspase-7 activation
in non-small cell lung cancer cell lines
(R)-(+)-Etomoxir Sodium Salt rtine Maleate PubMed Central PMCID: PMC4471626Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase 1 (CPT 1) on the outer face of the inner mitochondrial membrane. This prevents the formation of acyl carnitines, a step that is necessary for the transport of fatty acyl chains from the cytosol into the intermembrane space of the mitochondria. This step is essential to the production of ATP from fatty acid oxidation. Etomoxir has also been identified as a direct agonist of PPAR.