PROTAC Mcl1 degrader-1 exetil) InChi: InChI=1S/C18H24O12S/c1-31-18(26)28-4-6-2-8(20)11-7(15(24)25)5-27-16(10(6)11)30-17-14(23)13(22)12(21)9(3-19)29-17/h2

Name: PROTAC Mcl1 degrader-1 exetil) InChi: InChI=1S/C18H24O12S/c1-31-18(26)28-4-6-2-8(20)11-7(15(24)25)5-27-16(10(6)11)30-17-14(23)13(22)12(21)9(3-19)29-17/h2
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Description

InChi: InChI=1S/C18H24O12S/c1-31-18(26)28-4-6-2-8(20)11-7(15(24)25)5-27-16(10(6)11)30-17-14(23)13(22)12(21)9(3-19)29-17/h2

U 72107 D4

Epub 2014 May 30

(2013) J Am Chem Soc

587871-26-9

PROTAC Mcl1 degrader-1 exetil) InChi: InChI=1S/C18H24O12S/c1-31-18(26)28-4-6-2-8(20)11-7(15(24)25)5-27-16(10(6)11)30-17-14(23)13(22)12(21)9(3-19)29-17/h2PROTAC Mcl1 degrader 1 (compound C3), a proteolysis targeting chimera (PROTAC), is a potently and selectively Mcl 1 inhibitor with an IC50 of 0. 78 M. PROTAC Mcl1 degrader 1 induces the ubiquitination and proteasomal degradation of Mcl 1 by introducing the E3 ligase cereblon (CRBN) binding ligand pomalidomide to Mcl 1 inhibitor S1 6 with M range affinity. Product information CAS Number: 2163793 38 0 Molecular Weight: 909. 84 Formula: C45H45BrN6O8S

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