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PRX-08066 - CAS# 866206-54-4 411575 (isomer 3) Harmston N

SKU: 51291952559

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Description

Harmston N

a region pertinent to mood disorders

Smiles: COC1=CC=CC=C1C1=CC(NC2=CC(CS(N)(=O)=O)=CC=C2)=NC=N1

9a-pentamethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-7-yl]oxy}-4

It showed selectivity for Ral relative to the GTPases Ras and RhoA and inhibited tumour xenograft growth to a similar extent to the depletion of Ral using RNA interference

PRX-08066 - CAS# 866206-54-4 411575 (isomer 3) Harmston NPRX 08066 is a a novel 5 hydroxytryptamine receptor 2B antagonist, reduces monocrotaline induced pulmonary arterial hypertension and right ventricular hypertrophy in rats. In the 5 HT(2B) expressing SI NET cell line, KRJ I, PRX 08066 inhibited proliferation (IC(50) 4. 6 x 10( 9)M) and 5 HT secretion (6. 9 x 10( 9)M) and decreased ERK1 2 phosphorylation and profibrotic growth factor synthesis and secretion (transforming growth factor beta 1 [TGFbeta1],

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