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also known as SM04690
Chemical Name: 2-(2-Chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3
InChi: InChI=1S/C25H26N8O/c1-5-26-25(34)17-6-8-19(9-7-17)33-24-22(23(30-33)16(2)3)21(10-11-27-24)32-14-20(28-15-32)18-12-29-31(4)13-18/h6-16H
67469-81-2
InChiKey: NYHXPFHFIMRKDS-UHFFFAOYSA-N
AZD-5438 702 also known as SM04690AZD5438 is a potent inhibitor of cyclin dependent kinase (cdk) 1, 2, and 9 (IC(50), 16, 6, and 20 nmol L, respectively). In vitro, AZD5438 showed significant antiproliferative activity in human tumor cell lines (IC(50) range, 0. 2 1. 7 micromol L), causing inhibition of the phosphorylation of cdk substrates pRb, nucleolin, protein phosphatase 1a, and RNA polymerase II COOH terminal domain and blocking cell cycling at G(2) M, S, and G(1) phases.
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