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Cilomilast produces a concentration-dependent increase in cAMP content in U937 cells
Van Horn S
Discovery of 2-Pyridylpyrimidines as the First Orally Bioavailable GPR39 Agonists
1007/s00586-014-3675-2
a reduction in bone resorption and a better anabolic/catabolic balance in chondrocytes[2]
M-110 0192 Cilomilast produces a concentration-dependent increaseM 110 is a inhibitor of protein arginine N methyltransferases (PRMTs). It is also a highly isoform selective, cell permeable and potent ATP competitive inhibitor of the PIM kinase family that prefers PIM 3, shown to inhibit the proliferation of prostate cancer cell lines with IC50s between 0. 6 to 0. 9 M, with no activity on normal human peripheral blood mononuclear cells up to 40 M. Product information CAS Number: 1395048 49 3 Molecular Weight: 445.
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