Human embryonic kidney (HEK) 293 cells expressing human tolllike receptor (hTLR) gene and an inducible secreted embryonic alkaline phosphatase (SEAP) reporter gene were incubated with CU-115 for 16 hours
InChiKey: WUEHURHTEPWPPO-QZTJIDSGSA-N
CAS Number: 54724-00-4
Smiles: CN1CCN(CC1)C1=CC(NC2C=C(C)NN=2)=NC(/C=C/C2C=CC=CC=2)=N1
Smiles: CC(C)NC[C@@H](O)COC1=CC=C(CC(N)=O)C=C1
S-(2-aminoethyl) Isothiourea (dihydrobromide) 684PADS tetrasodium Human embryonic kidney (HEK) 293S (2 aminoethyl) Isothiourea (dihydrobromide) is a potent and non selective inhibitor of NOS with Ki values of 1. 8, 2. 1, and 0. 59 M for human nNOS, eNOS, and iNOS, respectively . In the brain, nitric oxide (NO), which is synthesized from L arginine (Arg) by NO synthase (NOS), acts as both an intra and an intercellular second messenger. Nitric oxide synthase (iNOS, eNOS, and nNOS) catalyzed the production of NO in the two step oxidation of L