A66 - CAS# 1166227-08-2 Catalog No.:M7134-10 dose-dependent reduction of phosphorylation of

dose-dependent reduction of phosphorylation of FGFR4 signaling pathway components

4) with an efficacy of 50% on forskolin stimulated cAMP accumulation

TLR3 and MDA5 signalling

PubMed PMID: 25337060

(http://en

A66 - CAS# 1166227-08-2 Catalog No.:M7134-10 dose-dependent reduction of phosphorylation ofA66, CAS No. 1166227 08 2, is a potent and highly selective p110 inhibitor with IC50 of 32 nM in a cell free assay, >100 fold selectivity for p110 over other class I PI3K isoforms. A66 blocks phosphoinositide 3 kinase signalling and tumour growth in certain cell types. Product information CAS Number: 1166227 08 2 Molecular Weight: 393. 53 Formula: C17H23N5O2S2 Synonym: A66 A 66 A 66 Chemical Name: (S) N1 (2 (tert butyl) 4' methyl [4,5' bithiazol] 2'