PKA Inhibitor Fragment (6-22) amide - CAS# 121932-06-7 ecrostatin-1 Smiles: CC(C)(C)[C@H](NC(=O)C1(F)CC1)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C=C1OCCCCCN1CCN(CC2C(=CC(=CC=2OC)C2=CN(C)C(=O)C3=CN=CC=C23)OC)CC1)C1SC=NC=1C

Smiles: CC(C)(C)[C@H](NC(=O)C1(F)CC1)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C=C1OCCCCCN1CCN(CC2C(=CC(=CC=2OC)C2=CN(C)C(=O)C3=CN=CC=C23)OC)CC1)C1SC=NC=1C

(-)-BAY-R-5417

Caspase-9 cleavage

GNE-7915 was reported as a potent (IC50=9 nM) selective (1/187 kinases)

26-1004 and 4-1318 xenografts and induces apoptosis in primary 2-1318 cells by activating the caspase pathway

PKA Inhibitor Fragment (6-22) amide - CAS# 121932-06-7 ecrostatin-1 Smiles: CC(C)(C)[C@H](NC(=O)C1(F)CC1)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C=C1OCCCCCN1CCN(CC2C(=CC(=CC=2OC)C2=CN(C)C(=O)C3=CN=CC=C23)OC)CC1)C1SC=NC=1CPKA Inhibitor Fragment (6 22) amide is an inhibitor of cAMP dependent protein kinase A (PKA), with a Ki of 2. 8 nM. PKA Inhibitor Fragment (6 22) amide can significantly reverse low level morphine antinociceptive tolerance in mice. Product information CAS Number: 121932 06 7 Molecular Weight: 1868. 06 Formula: C80H130N28O24 Synonym: PKI (6 22) amide Chemical Name: (3S) 4 [[(2S) 1 [[(2S, 3S) 1 [[(2S) 1 [[(2S) 1 [[2 [[(2S) 1 [[(2S, 3R) 1 [[2 [[(2S) 1