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3-b]pyridin-3-yl}prop-2-en-1-one hydrochloride
N-Dimethylthioxanthene-delta(sup 9
PubMed PMID: 11456011
InChi: InChI=1S/C17H20N4O5
InChiKey: OQGRFQCUGLKSAV-JTQLQIEISA-N
GSK2126458 - CAS# 1086062-66-9 Size:Solid 2 mg 3-b]pyridin-3-yl}prop-2-en-1-one hydrochlorideOmipalisib, also known as GSK2126458, is a small molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3 kinase (PI3K) with potential antineoplastic activity. PI3K inhibitor GSK2126458 binds to and inhibits PI3K in the PI3K mTOR signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability and inducing apoptotic cell death. Bax is a member of the