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Formula: C21H19NO3S
FH535 selectively inhibits cell proliferation and potentiates imatinib-induced apoptosis in myeloid leukemia cell lines
InChiKey: WSMXAUJFLWRPNT-DIVCQZSQSA-N
CAS Number: 71617-10-2
which expressed mutated FGFR3 protein
K-7174 dihydrochloride iophen-2-yl)-2-(2-(m-tolyl)hydrazono)butane-1 3-dione Formula: C21H19NO3SK 7174 is a novel orally active, potent proteasome inhibitor. K 7174 exerts anti myeloma activity in vitro and in vivo by down regulating the expression of class I histone deacetylases. K 7174 kills bortezomib resistant myeloma cells carrying a 5 subunit mutation in vivo and primary cells from a patient resistant to bortezomib. K 7174 is also a GATA specific inhibitor, which may have potential application in treating anemia of chronic disease. Product