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irreversible pan-caspase inhibitor
being 14- and 24-fold less active compared with HER2
is a AMPA receptor agonist potentially for the treatment of major depression and anxiety
with an EC50 of 260 nM
Harashima H
BMS-564929 0364 irreversible pan-caspase inhibitorBMS 564929 is a highly potent, orally active, nonsteroidal tissue selective androgen receptor (AR) modulator. BMS 564929 is a subnanomolar AR agonist in vitro, is highly selective for the AR vs. other steroid hormone receptors, and exhibits no significant interactions with SHBG or aromatase. Dose response studies in castrated male rats show that BMS 564929 is substantially more potent than testosterone (T) in stimulating the growth of the levator ani
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