BIBS 39 odoHoechst 33258 C2H4O2/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12

C2H4O2/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12

Pistarà V

InChi: InChI=1S/C20H20O5/c1-11-12(2)20(14-4-6-16-18(8-14)24-10-22-16)25-19(11)13-3-5-15-17(7-13)23-9-21-15/h3-8

and has the potential in targeting eIF4E for solid cancers

Andrea Pawellek et al

BIBS 39 odoHoechst 33258 C2H4O2/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12BIBS 39 is a new nonpeptide angiotensin II (AII) receptor antagonist. Target: Angiotensin Receptorin vitro: BIBS 39 displaces [125I] AII from its specific binding sites with a Ki value of 29 7 nM for the AII subtype 1 (AT1) receptor and a Ki value of 480 110 nM for the AII subtype 2 (AT2) receptor. BIBS 222 shows a Ki value of 20 7 nM for the AT1 subtype and a Ki value of 730 170 nM for the AT2 subtype. BIBS 39 is 17 times more selective for the AT1