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Sahakian E
CHEMBL83980
Smiles: FC(F)(F)C1=NN=C2C=CC(=CN21)C1C=CC(=CC=1)OC(F)(F)F
J Biol Chem
3(12):1025-36
EX-527 (S) Catalog No.:M8466-2 Sahakian ESelisistat racemate is a racemic mixture of EX 527, an inhibitor of sirtuin 1 (SIRT1; IC50 = 0. 098 M). 1 It is selective for SIRT1 over SIRT2, and SIRT3 (IC50s = 19. 6 and 48. 7 M, respectively) and the cytochrome P450 (CYP) isoforms CYP3A4, CYP2D6, CYP2C9, CYP2C19, and CYP1A2 at 1 M. EX 527 (50 M) induces cell cycle arrest at the G1 phase in MCF 7 cells. Product information CAS Number: 848193 68 0 Molecular Weight: 248. 71 Formula: C13H13ClN2O
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