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OSI-027 showed superior efficacy compared with rapamycin
induces apoptosis in NSCLC cells
A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes
2(4):401-8
1883548-89-7
ML323 - USP1-UAF1 Inhibitor. CAS# 1572414-83-5 size:2 mg solid OSI-027 showed superior efficacy comparedML323, CAS No. 1572414 83 5, is a potent, selective and reversible inhibitor of the USP1 UAF1 deubiquitinase complex with IC50 ~76 nM in the Ub Rho assay. It has excellent selectivity against human DUBs, deSUMOylase, deneddylase and unrelated proteases, showed little to no inhibition against other USPs tested, including USP2, USP5, USP7, USP8, USP10, USP11, USP14 and USP21. Inhibition mechanism and HDX studies suggest that ML323 binds away from the
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