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Brain-penetrant LSD1 inhibitors can block memory consolidation
CAS Number: 300586-90-7
Binding of >50% probe displacement is detected for 10 kinases and of >65% for only LRRK2
CAS Number: 1604810-83-4
TUG-770 (Compound 22
CPI-637 - CAS# 1884712-47-3 60010 Brain-penetrant LSD1 inhibitors can blockCPI 637, CAS No. 1884712 47 3, is a potent and selective CBP EP300 bromodomain inhibitor. The biochemical potency of CPI 637 translated well into cells (CBP BRET EC50 = 0. 3 M). CPI 637 demonstrated a >700 fold selectivity over the BET family of bromodomains (BRD4 IC50 = 11. 0 0. 6 M). CPI 637 inhibits MYC expression in AMO 1 cells (EC50 = 0. 60 M). CBP and EP300 are highly homologous, bromodomain containing transcription coactivators involved in
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