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InChi: InChI=1S/C32H35N5O5/c1-42-26-15-9-23(10-16-26)32(17-5-2-6-18-32)21-34-30(38)29(19-22-20-33-28-8-4-3-7-27(22)28)36-31(39)35-24-11-13-25(14-12-24)37(40)41/h3-4
the insulin receptor
Efficient non-viral reprogramming of myoblasts to stemness with a single small molecule to generate cardiac progenitor cells
Zhongguo Zhong Yao Za Zhi
(2012) Proc Natl Acad Sci U S A
NVP-ADW742 Catalog No.:M7898-10 InChi: InChI=1S/C32H35N5O5/c1-42-26-15-9-23(10-16-26)32(17-5-2-6-18-32)21-34-30(38)29(19-22-20-33-28-8-4-3-7-27(22)28)36-31(39)35-24-11-13-25(14-12-24)37(40)41/h3-4NVP ADW742, also known as ADW 742 or GSK 552602A, is a novel small weight molecular inhibitor of IGF IR with potential anticancer activity. NVP ADW742 inhibited IGF IR mediated proliferation with an IC50 of 11. 12 mol l. NVP ADW742 induced early suppression of Akt, P38 and GSK 3 phosphorylation. NVP ADW742 enhanced the chemosensitivity of Daoy to temozolomide in vitro, as a potent anti tumor agent highly selective against IGF IR. NVP ADW742 was found
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