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Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride)
selective and irreversible inhibitor of factor XIa
α-Cyano-4-hydroxycinnamic acid inhibits mitochondrial pyruvate transporter with a Ki of 6
Synthesis and biological evaluation of 3-substituted 2-oxindole derivatives as new glycogen synthase kinase 3β inhibitors
InChi: InChI=1S/C22H23N7O/c1-14-9-18(26-29-11-15(2)24-21(14)29)17-10-20(30)28-12-16(3-4-19(28)25-17)27-8-7-23-22(13-27)5-6-22/h3-4
Sulindac sulfone Size:Contact [email protected] for quotation Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride)Sulindac sulfone is a metabolite of the nonsteroidal anti inflammatory drug (NSAID) sulindac. In vitro: Sulindac sulfone treatment also inhibited PGE2 production by HCA 7 cells with an IC50 of 360 mmol L. Sulindac sulfone at 100 mmol L reduced 6 ketoPGF by 29. 2%. Sulindac sulfone reduced the colony number of HCA 7 and HCT 116 with an EC50 of 50 mmol l. Sulindac sulfone significantly decreased the expression of total cellular catenin (50% of control),
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