KHS-101 free base Catalog No.:M33592-10 COC1C=CC=C(CCC2=CC=CC=C2OCC(CN(C)C)OC(=O)CCC(O)=O)C=1

COC1C=CC=C(CCC2=CC=CC=C2OCC(CN(C)C)OC(=O)CCC(O)=O)C=1

Smiles: C[C@H](N[P@@](=O)(OC1C=CC=CC=1)OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@](C)(F)[C@@H]1O)C(=O)OCC

Formula: C17H17NO

Simvastatin Acyl-β-D-glucuronide is a metabolite of Simvastatin

Epub 2012 Nov 12

KHS-101 free base Catalog No.:M33592-10 COC1C=CC=C(CCC2=CC=CC=C2OCC(CN(C)C)OC(=O)CCC(O)=O)C=1KHS 101 is a selective inducer of neuronal differentiation. KHS101 induces neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs) by interacting with TACC3 (EC50 ~1 M). KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice. KHS101 promoted tumor cell death in diverse GBM cell models. KHS101 exerted cytotoxic effects by disrupting the mitochondrial chaperone heat shock protein family D