MIRA-1 idinium bromide 14bS)-3-(acetyloxy)-4

14bS)-3-(acetyloxy)-4

Chemical Name: N-((3-fluoro-2'-methyl-2

InChi: InChI=1S/C8H14O4/c9-7(10)5-3-1-2-4-6-8(11)12/h1-6H2

2)10-17(24)19(14)20/h9

InChi: InChI=1S/C22H26N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h4-8

MIRA-1 idinium bromide 14bS)-3-(acetyloxy)-4MIRA 1 is a maleimide derived small molecule that reactivates the tumor suppressor function of mutant p53, inducing apoptosis in several human solid tumor cell lines carrying tetracycline regulated mutant p53 (IC50 = 10 M in vitro). 1 Treatment of tumor cells with MIRA 1 induces p21, MDM2 and PUMA in a mutant p53 dependent manner. At a concentration of 5 10 mg kg, MIRA 1, alone or in combination with dexamethasone , arrested tumor growth in a mouse