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InChi: InChI=1S/C14H7ClFN3O5/c15-10-5-7(1-3-11(10)16)18-14(21)9(13(20)17-18)6-8-2-4-12(24-8)19(22)23/h1-6H
2010 Apr 15
MK-2048 represents a prototype second-generation integrase strand transfer inhibitor (INSTI) developed with the goal of retaining activity against viruses containing mutations associated with resistance to first-generation INSTIs
Formula: C18H19N5O4S
Recent studies showed that risk of major coronary events not reduced by darapladib therapy
Methylnissolin EP-37440 InChi: InChI=1S/C14H7ClFN3O5/c15-10-5-7(1-3-11(10)16)18-14(21)9(13(20)17-18)6-8-2-4-12(24-8)19(22)23/h1-6HMethylnissolin (Astrapterocarpan), isolated from Astragalus membranaceus, inhibits platelet derived growth factor (PDGF) BB induced cell proliferation with an IC50 of 10 M. Methylnissolin inhibits PDGF BB induced phosphorylation of extracellular signal regulated kinase 1 2 (ERIC1 2) mitogen activated protein (MAP) kinase. Methylnissolin inhibits PDGF BB induced vascular smooth muscle cell proliferation by inhibition of the ERK1 2 MAP kinase cascade.
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