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TUG-770 (Compound 22) displays excellent physicochemical and in vitro ADME properties
6(9):e25093
4-difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine
109(4):360-4
Fmoc-Val-Cit-PAB-OH
Fatostatin A - Sterol Regulatory Binding Proteins (SREBPs) Inhibitor. CAS# 125256-00-0 60129 TUG-770 (Compound 22) displays excellentFatostatin A, CAS No. 125256 00 0, is a highly potent, specific and cell permeable inhibitor of Sterol Regulatory Binding Proteins (SREBPs). It inhibits the ER Golgi translocation of SREBPs via binding to their escort protein (SCAP). It blocks adipogenesis by inhibiting the activation of SREBP 1 and SREBP 2. It exhibits anti proliferative effects on DU 145 cells independently of IGF 1 signaling (IC50 ~0. 1 M). Fatostatin A can prevent increases in
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