Dot1L-IN-4 Catalog No.:M27747-C In vitro binding affinity (Ki)

In vitro binding affinity (Ki) and kinetics (half-life ‘T1/2′ in minutes) for HDAC 1

SB505124 (10 µM) impairs Smad2 phosphorylation and CTGF and α-SMA expression in vitro

Smiles: NC1=NC(F)=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O

Smiles: NC1=CC=C(C=N1)C(N)=O

4)32)20(27)12-17-29(22

Dot1L-IN-4 Catalog No.:M27747-C In vitro binding affinity (Ki)Dot1L IN 4 is a potent disruptor of telomeric silencing 1 like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0. 11 nM. Product information CAS Number: 2565705 02 2 Molecular Weight: 661. 08 Formula: C28H27ClF2N8O5S Chemical Name: N1 [(S) (3 chloropyridin 2 yl)(2,2 difluoro 2H 1,3 benzodioxol 4 yl)methyl] 4 methanesulfonyl N2 [4 methoxy 6 (piperazin 1 yl) 1,3,5 triazin 2 yl]benzene 1,2 diamine Smiles: